Metabolite pattern in plasma, urine, bile, and feces after subcutaneous administration of 30 μg [3H]1-degarelix/kg in rats (rat study R1)
| Gender | Sample | Sampling Period | Percentage of Component in Samplea | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| [3H]1-Degarelix | FE 200486 (1–4)-OH | FE 200486 (1–6)-OH | FE 200486 (1–5)-OH | FE 200486 (1–9)-OH | FE 200486 (1–7)-OH | U | U | FE 200486 (1–10)-OH | |||
| h | |||||||||||
| Male | Plasma | 0–24 | 87.4 | 12.6 | |||||||
| Urineb | 0–48 | 96.4 | 0.44 | 0.17 | 0.32 | 0.17 | 0.53 | ||||
| Bileb | 0–48 | 17.2 | 25.9 | 30.5 | 1.17 | 9.98 | 13.3 | ||||
| Fecesb | 0–48 | 5.84 | 25.7 | 19.2 | 12.9 | 15.5 | 3.90 | 14.4 | |||
| Female | Plasma | 0–24 | 94.3 | 5.75 | |||||||
| Urineb | 0–48 | 92.4 | 2.97 | 2.97 | 0.07 | 0.17 | 0.12 | 0.64 | |||
| Bile | 0–48 | 28.3 | 24.9 | 23.4 | 1.36 | 7.91 | 14.1 | ||||
| Fecesb | 0–48 | 5.95 | 26.6 | 12.0 | 9.95 | 15.2 | 3.15 | 24.7 | |||
U, unknown.
a Numbers represent mean values of four individual animals.
b Radioactivity detected in void peak adds up to 100%.