CYP2D6 | CYP3A4 | CYP3A5 | |
---|---|---|---|
M1 | |||
Vmax (pmol/min/mg) | 1.0 ± 0.1 | 8.5 ± 0.2 | 5.8 ± 0.5 |
Km (μM) | 4.8 ± 1.2 | 9.3 ± 0.9 | 29.3 ± 6.4 |
Intrinsic clearance (μl/min/mg) | 0.2 | 0.9 | 0.2 |
M2 | |||
Vmax (pmol/min/mg) | 0.1 ± 0.01 | 1.4 ± 0.1 | 1.4 ± 0.04 |
Km (μM) | 22.0 ± 4.7 | 21.6 ± 3.0 | 16.4 ± 1.5 |
Intrinsic clearance (μl/min/mg) | <0.01 | 0.1 | 0.1 |