TABLE 2

Pharmacokinetics of GDC-0834 and M1 in PXB and SCID mice

Treatment & AnalyteAUC0–∞CLVssM1/Parent AUC Ratio
h · μMml · min1 · kg1l/kg
PXB i.v.
    GDC-08341.3021.50.507N.A.
    M10.644N.A.N.A.0.495
SCID i.v.
    GDC-08341.8315.30.435N.A.
    M10.0205N.A.N.A.0.0112
    PXB p.o.
        GDC-08342.2835%aN.A.N.A.
        M11.69N.A.aN.A.0.741
    SCID p.o.
        GDC-08342.8831%aN.A.N.A.
        M10.267N.A.aN.A.0.0927
  • N.A., not available.

  • a bioavailability.