Effect of preincubation on inhibition of CYP2D6 activity by major phytocannabinoids
All determinations were performed in duplicate.
| Cannabinoids | IC50 (μM) | B/A | |
|---|---|---|---|
| Preincubation Time | |||
| 0 min (A) | 20 min (B) | ||
| Δ9-THC | 19.6 | 22.7 | 1.16 |
| CBD | 6.65 | 4.64 | 0.698 |
| CBN | 16.0 | 21.9 | 1.37 |