In vivo predictions in rat and dog
| Compound | Species | Hepatic Metabolic Clearance | Vss | |||
|---|---|---|---|---|---|---|
| Predicted (Method) | Observed | Predicted Media Loss | Observed Media Loss | |||
| Cells and Media | Media Loss | |||||
| ml · min−1 · kg−1 | l/kg | |||||
| Ibuprofen | Rat | 13.3 | 5.7 | 2.4, 1.5 | 0.17 | 0.2, 0.2 |
| Indomethacin | Rat | 0.9 | 0.61 | 0.2, 0.3 | 0.19 | 0.1, 0.1 |
| Losartan | Rat | 3.9 | 19 | 4.1, 4.4 | 1.5 | 2.0, 1.2 |
| Ramatroban | Rat | 5.1 | 26 | 15, 13 | 1.8 | 1.3, 1.3 |
| Sulfisoxazole | Rat | 0.6 | 0.23 | 0.1, 0.1 | 0.17 | 0.2, 0.2 |
| Telmisartan | Rat | 2.0 | 4.9 | 5.8, 7.3 | 0.7 | 2.4, 2.7 |
| Tolmetin | Rat | 2.0 | 0.86 | 1.5 ± 0.4 | 0.12 | 0.11 ± 0.03 |
| AZ1 | Rat | 1.1 | 3.9 | 5.6 ± 2.4 | 1.0 | 0.9 ± 0.2 |
| AZ2 | Rat | 0.6 | 4.7 | 6.1 ± 1.8 | 0.83 | 0.6 ± 0.3 |
| Ibuprofen | Dog | 1.3 | 1.5 | 0.5, 0.7 | 0.14 | 0.08, 0.07 |
| Indomethacin | Dog | 2 | 9.3 | 3.8, 2.1 | 0.25 | 0.09, 0.05 |
| Losartan | Dog | 8 | 30 | 24, 34 | 1.1 | 0.4, 0.3 |
| Ramatroban | Dog | 6 | 17 | 7.6 ± 3.4 | 1.2 | 2.2 ± 1.4 |
| Sulfisoxazole | Dog | 7 | 1.5 | 0.2 ± 0.2 | 0.60 | 0.3 ± 0.1 |
| Telmisartan | Dog | 5 | 1.7 | 4.1, 2.3 | 0.60 | 0.7, 0.4 |
| Tolmetin | Dog | 1.7 | 0.8 | 0.3, 0.7 | 0.25 | 0.1, 0.4 |
| AZ1 | Dog | 0.7 | 1.8 | 1.5, 0.8 | 0.25 | 0.2, 0.4 |
| AZ2 | Dog | 1 | 2.6 | 0.9, 2.0 | 0.45 | 0.4, 0.3 |