TABLE 5

Prediction accuracy for the prediction of human V_ss by interspecies scaling and Simcyp methods

Predicted by		Percentage of All Compounds Predicted within
Predicted by		1.5-Fold	2-Fold	3-Fold
V_ss,u from	Rat	36	55	79
	Dog	37	54	81
	Monkey	37	64	81
	Average	40	72	87
f_ut^{^a} from	Rat	39	55	82
	Dog	43	63	84
	Monkey	43	67	81
	Average	55	75	90
f_ut^{^b} from	Rat	36	54	84
	Dog	48	69	85
	Monkey	40	66	84
	Average	58	78	90
Allometry of	V_ss	30	60	73
	V_ss,u	28	55	75
Simcyp	Method 1	19	40	67
	Method 2	15	43	64