Excretion of major metabolites in rat bile after oral administration of S-7-G
Three rats were orally administered S-7-G at a dose of 75 mg/kg, and bile was collected over the 30-h period after dose.
| Metabolite | Excretion Amount | Percentage | |||
|---|---|---|---|---|---|
| No. 1 | No. 2 | No. 3 | Average | ||
| μg | % | ||||
| Glucuronide conjugate (M2) | 7285 | 7536 | 6413 | 7078 | 55.0 |
| S-7-G (M0-1) | 3679 | 3731 | 3399 | 3603 | 28.0 |
| Methylated M0 (M4) | 611 | 634 | 798 | 681 | 5.30 |
| S-6-G (M0-2) | 607 | 701 | 671 | 660 | 5.13 |
| Glucose conjugate (M3) | 595 | 749 | 472 | 605 | 4.71 |
| S (M1) | 162 | 340 | 105 | 202 | 1.57 |
| Methylated aglycone (M5) | 27.8 | 31.9 | 27.0 | 28.9 | 0.224 |
| Total excretion | 12968 | 13723 | 11885 | 12859 | |
| Recovery of dose (%) | 45.1 | 44.6 | 42.8 | 44.2 | |