AdCYP2C9 + AdPGRMC1 | S-Warfarin 7-Hydroxylation | Diclofenac 4′-Hydroxylation | ||||
---|---|---|---|---|---|---|
Km | Vmax | Vmax/Km | Km | Vmax | Vmax/Km | |
μM | pmol · min−1 · pmol P450−1 | μl · min−1 · pmol P450−1 | μM | pmol · min−1 · pmol P450−1 | μl · min−1 · pmol P450−1 | |
1.6 ± 0.1 | 5.4 ± 0.2 | 3.3 ± 0.2 | 7.3 ± 0.3 | 91.6 ± 6.8 | 12.6 ± 1.5 | |
×1 | 1.6 ± 0.1 | 3.3 ± 0.2* | 2.0 ± 0.1* | 8.1 ± 0.5 | 72.9 ± 4.7* | 9.0 ± 0.5* |
×2 | 1.7 ± 0.2 | 2.4 ± 0.2** | 1.5 ± 0.1** | 7.1 ± 2.7 | 52.5 ± 15.5** | 7.5 ± 0.5** |
×4 | 1.7 ± 0.2 | 1.7 ± 0.1** | 1.0 ± 0.1** | 8.4 ± 0.6 | 42.2 ± 6.7** | 5.0 ± 0.5** |
↵* P < 0.05 and ** P < 0.01 compared with control by Shirley-Williams' test.