IC50 values of the major phytocannabinoids for inhibition of AMMC and dextromethorphan O-demethylase activities of recombinant CYP2D6 and HLMs
| Enzymes | Substrates | IC50 (μM) | ||
|---|---|---|---|---|
| Δ9-THC | CBD | CBN | ||
| CYP2D6 | AMMC | 21.2 | 6.52 | 24.0 |
| CYP2D6 | Dextromethorphan | 17.1 | 6.01 | 12.3 |
| HLMs | Dextromethorphan | 22.9 | 4.01 | 24.9 |