Excretion of major metabolites in rat urine after oral administration of S-7-G
Three rats were orally administered S-7-G at a dose of 75 mg/kg, and urine was collected over the 36-h period after dose.
| Metabolite | Excretion Amount | Percentage | |||
|---|---|---|---|---|---|
| No. 1 | No. 2 | No. 3 | Average | ||
| μg | % | ||||
| Glucuronide conjugate (M2) | 414 | 488 | 261 | 388 | 41.6 |
| S-7-G (M0-1) | 377 | 440 | 323 | 380 | 40.8 |
| S (M1) | 75.8 | 102 | 52.7 | 76.7 | 8.23 |
| S-6-G (M0-2) | 44.0 | 50.9 | 28.1 | 41.0 | 4.40 |
| Methylated M0 (M4) | 35.9 | 18.4 | 20.8 | 25.0 | 2.69 |
| Glucose conjugate (M3) | 27.5 | 23.6 | 13.3 | 21.5 | 2.30 |
| Total excretion | 974 | 1123 | 699 | 932 | |
| Recovery of dose (%) | 5.96 | 6.24 | 4.05 | 5.42 | |