Transporter mRNA expression levels (relative to GAPDH) in cultured epithelial cells
Results are n = 3 repeats.
| Cell Line | BCRP (ABCG2) | bcrp1 (abcg2) | MRP4 (ABCC4) |
|---|---|---|---|
| WT-MDCKII | 0.71 ± 0.16 | ||
| bcrp1-MDCKII | 0.02 ± 0.01 | 3803.80 ± 504.12 | |
| BCRP-MDCKII | 20389.59 ± 377.91 | ||
| WT-HEK293 | 0.42 ± 0.05 | ||
| MRP4-HEK293 | 94.67 ± 2.39 | ||
| Low PA Caco-2 | 26.87 ± 0.69 | 2.12 ± 0.18 | |
| High PA Caco-2 | 0.43 ± 0.08 | 0.08 ± 0.01 |