Mean areas under the curve (±S.E.M.) from 0 to 4 h of individual plasma and brain ECF concentration-time profiles per study and matrix
| Dose (mg/kg) | Intravenous Study | Intranasal Study | ||||
|---|---|---|---|---|---|---|
| Plasma AUC | Brain ECF AUC | Brain ECF AUC/Plasma AUC | Plasma AUC | Brain ECF AUC | Brain ECF AUC/Plasma AUC | |
| μg · min/ml | μg · min/ml | % | μg · min/ml | μg · min/ml | % | |
| 4 | 44.9 (7.7) | 7.9 (1.7) | 17.5 | 10.8 (2.9) | —a | — |
| 8 | 70.1 (4.7) | 14.0 (0.7) | 19.9 | 20.0 (5.5) | 4.9 (0.8) | 24.7 |
| 16 | 173.0 (9.0) | 34.6 (7.1) | 20.0 | 53.9 (11.4) | 16.7 (2.4) | 31.0 |
| Mean brain/plasma AUC per study | 19 (0.8) | 28 (2.6) | ||||
↵a Not determined.