CYP2C19 activity before and after dialysis
| Compound | CYP2C19 Inactivation (30 min) | Inhibition | ||
|---|---|---|---|---|
| Before Dialysis | After Dialysis | |||
| 6 H | 12 H | |||
| % | ||||
| Isoniazid | + NADPHa | 93.5 | 89.6 | 85.2 |
| − NADPHa | 75.4 | 52.0 | 27.8 | |
| Protopine | + NADPHa | 90.7 | 91.4 (4 h) | 94.1 (10 h) |
| − NADPHa | 87.3 | 81.9 (4 h) | 52.6 (10 h) | |
| Bulbocapnine | + NADPHa | 91.9 | 89.1 | 86.0 |
| − NADPHa | 87.3 | 27.9 | 23.4 | |
| Canadine | + NADPHa | 91.7 | 87.5 | 80.0 |
| − NADPHa | 88.3 | 86.3 | 49.6 | |
| Tranylcypromine | + NADPHa | 73.8 | 30.6 | 0 |
| − NADPHa | 75.3 | 27.2 | 0 | |
↵a The NADPH-regenerating system.