Relative abundance of urinary and fecal metabolites of CP-945,598 in male and female mice after oral administration of [14C]CP-945,598
| Metabolite | Dose Excreted | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Males | Females | Mean | |||||||
| Urine | Feces | Total | Urine | Feces | Total | Urine | Feces | Total | |
| % | |||||||||
| Parent (X) | |||||||||
| M1 | 0.4 | 17.3 | 17.7 | 0.1 | 20.0 | 20.1 | 0.3 | 18.7 | 18.9 |
| M2 | 1.0 | 31.2 | 32.2 | 1.1 | 28.6 | 29.7 | 1.1 | 29.9 | 31.0 |
| M3 | 0.2 | 5.6 | 5.8 | 0.1 | 5.0 | 5.1 | 0.2 | 5.3 | 5.5 |
| M4 | 0.2 | 0.8 | 1.0 | 0.1 | 1.0 | 1.1 | 0.2 | 0.9 | 1.1 |
| M5 | 0.8 | 0.8 | 1.2 | 1.2 | 1.0 | 1.0 | |||
| M6 | 0.8 | 10.6 | 11.4 | 10.5 | 10.5 | 10.6 | 10.6 | ||
| M9a | 2.1 | 2.1 | 2.4 | 2.4 | 2.3 | 2.3 | |||
| M9b | 4.4 | 4.4 | 4.2 | 4.2 | 4.3 | 4.3 | |||
| M9c | 1.9 | 1.9 | 1.2 | 1.2 | 1.6 | 1.6 | |||
| M12 | 9.8 | 9.8 | 10.5 | 10.5 | 10.2 | 10.2 | |||
| M14 | 0.2 | 2.4 | 2.6 | 0.1 | 1.4 | 1.5 | 0.2 | 1.9 | 2.1 |
| M15a | 1.3 | 1.3 | 0.9 | 0.9 | 1.1 | 1.1 | |||
| M15b | 0.9 | 0.9 | 0.6 | 0.6 | 0.8 | 0.8 | |||
| M20 | 0.3 | 1.0 | 1.3 | 0.1 | 0.6 | 0.7 | 0.2 | 0.8 | 1.0 |
| M22 | 1.1 | 1.1 | 1.1 | 1.1 | 1.1 | 1.1 | |||
| M26 | 1.0 | 1.0 | 0.9 | 0.9 | 1.0 | 1.0 | |||