TABLE 3

Metabolites of SB939 formed, in vitro, after incubation in human, mouse, dog, and rat liver microsomes based on LC-MS/MS analysis

PeakDescriptionMolecular Ionm/zRetention Time
HLMMLMDLMRLM
min
MSB939 (parent)MH+35914.314.614.614.5
M1N-deethylationMH+ − 2833112.813.113.113.0
M2OxidationMH+ + 163759.0a8.9aNDND
M3OxidationMH+ + 1637510.6a10.6a10.7a10.7a
M4OxidationMH+ + 16375NDNDND12.3
M5N-deethylation and oxidationMH+ − 12347ND8.3aND8.8a
M6bis-N-deethylationMH+ − 5630311.711.811.911.3a
M7OxidationMH+ + 14373NDNDND11.4a
M8ReductionMH+ − 1634316.5a16.516.516.4
  • ND, not detected.

  • a The retention times are from XIC (data not shown).