Calculated unbound fraction of barbiturates in rat microsomal preparations (mean fumic, ± S.E., n = 3)
| Microsomal Concentration | n-Pentyl | n-Hexyl | n-Heptyl | n-Octyl | n-Nonyl |
|---|---|---|---|---|---|
| mg/ml | |||||
| 0.2 | 0.95 (±0.006) | 0.90 (±0.012) | 0.83 (±0.010) | 0.77 (±0.033) | 0.45 (±0.063) |
| 0.5 | 0.90 (±0.001) | 0.81 (±0.005) | 0.64 (±0.006) | 0.40 (±0.005) | 0.27 (±0.009) |
| 1.0 | 0.95 (±0.041) | 0.73 (±0.008) | 0.49 (±0.001) | 0.25 (±0.012) | 0.18 (±0.008) |