IC50 values for the inhibition by loperamide of 4NPB hydrolysis by each CES studied
| Human | Cynomolgus Monkey | Beagle Dog | |||||
|---|---|---|---|---|---|---|---|
| hCES1 | hCES2 | hCES3 | cCES1 | cCES2 | dCES1 | dCES2 | |
| IC50 (μM) | 464 | 0.562 | >500 | >500 | 34.4 | >500 | 93.6 |
| 95% CI (μM) | 374–577 | 0.476–0.663 | N.A. | N.A. | 24.0–49.5 | N.A. | 75.3–116.5 |
N.A., not applicable; CI, confidence interval.