TABLE 2

Mean pharmacokinetic parameters for unchanged CP-945,598 in rats, dogs, and mice after oral administration of [¹⁴C]CP-945,598

Animals	T_max	C_max	AUC_{(0–t last)}	AUC_(0–∞)	t_1/2
	h	ng/ml	ng · h/ml		h
Male rats (n = 3)	1.3	1456	4575	4645	3.6
Female rats (n = 3)	2.8	2670	36,145	36,507	5.0
Mean	2.1	2063	20,360	20,576	4.3
Male mice (n = 3)/cage	1.0	520	1390	N.A.	2.8
Female mice (n = 3)/cage	1.0	2130	3690	N.A.	1.8
Mean	1.0	1325	2540	N.A.	2.3
Male dogs (n = 2)	1.0	819	5570	5790	5.2
Female dogs (n = 2)	0.8	637	2930	3040	5.8
Mean	0.9	728	4250	4415	5.5