TABLE 2

Human peak plasma concentrations ([I]) and Kis values for AOX inhibitors

[I]/Kis represents an estimate of the likelihood of drug interactions in vivo.

InhibitorKis[I]/Kis
nM
Ethinyl estradiol0.44a11000.0004
β-Estradiol12b9000.01
Clozapine1700c39000.4
Chlorpromazine470d6200.8

  • ↵a For normal women given a 30-μg dose (Westhoff et al., 2010).

  • ↵b In pregnant women (Piwowarska et al., 2010).

  • ↵c For patients given a 150-mg dose twice a day for 7 days (Brunton et al., 2006).

  • ↵d For patients given 100 mg/day for 30 days (Dahl and Strandjord, 1977).