TABLE 1

Physiological parameters at different time points in four groups

	Baseline before CA	1 H after Resuscitation	End of Cooling Induction, PK Baseline	4 H after Cooling	8 H after Cooling
MAP
Sham normothermia	101.7 ± 7.5	92.7 ± 8.8	102.8 ± 13.8	125.8 ± 16.4	115 ± 15.2
Sham hypothermia	110.6 ± 29.5	100.3 ± 11.5	119.5 ± 17.4	131.7 ± 21.9	129.2 ± 14.5
CA normothermia	109 ± 27.9	59.3 ± 14.4^{^†}	86.3 ± 21.3	110 ± 5.8	136.5 ± 11.9^#
CA hypothermia	88 ± 11.5	69.2 ± 16.8^{^#,^†}	138.6 ± 12.9^{^#,^†}	130.5 ± 20.5^#	126.3 ± 9.9^#
PaCO₂
Sham normothermia	37.9 ± 5.9	36.4 ± 4.4	35.8 ± 4.2	35.2 ± 3.4	34.8 ± 4.4
Sham hypothermia	37.1 ± 4.5	37.2 ± 2.4	40.1 ± 5.1	36.8 ± 7.1	30.8 ± 3.7^#
CA normothermia	39.3 ± 3.2	32.4 ± 5.4^#	36.7 ± 4.1	39.6 ± 8.0	35.4 ± 5.3
CA hypothermia	36.5 ± 2.6	29.1 ± 2.3^{^#,^†}	49.7 ± 5.9^{^#,^†}	42.9 ± 5.5^{^#,^†}	36.9 ± 8.3
Glucose
Sham normothermia	86.8 ± 20.2	65.7 ± 8.07^#	69.7 ± 10.9^#	78.2 ± 18.6	75.3 ± 23.5
Sham hypothermia	113.5 ± 30.7	76.8 ± 16.6^#	87.8 ± 19.1^#	83.8 ± 18.2^#	89.2 ± 17.4^#
CA normothermia	112 ± 39.9	63.6 ± 11.8^#	56 ± 5.5^{^#,^†}	85.2 ± 28.2^#	71 ± 30.3^#
CA hypothermia	92.6 ± 17.0	53 ± 13.4^{^#,^†}	72.8 ± 29.6^#	80.7 ± 16.7^#	73.3 ± 38.1^#
Lactate
Sham normothermia	0.78 ± 0.23	0.78 ± 0.29	0.82 ± 0.36	0.32 ± 0.30^#	0.5 ± 0.25^#
Sham hypothermia	0.96 ± 0.24	0.9 ± 0.35	0.56 ± 0.23^#	0.62 ± 0.23^{^#,^†}	0.4 ± 0.34^#
CA normothermia	0.82 ± 0.18	1.40 ± 0.7^{^†}	0.7 ± 0.4	0.8 ± 0.23^{^†}	1.32 ± 1.5^{^#,^†}
CA hypothermia	0.96 ± 0.31	0.88 ± 0.48	0.25 ± 0.13^{^#,^†}	0.47 ± 0.25^{^#,^†}	0.38 ± 0.11^{^#,^†}
BUN
Sham normothermia	24.7 ± 7.3	22.5 ± 4.5	23.5 ± 6.0	38 ± 12.7^#	57.8 ± 19.7^#
Sham hypothermia	23.2 ± 5.6	24 ± 3.8	23.2 ± 4.6	37.2 ± 10.3^#	49.2 ± 16.7^#
CA normothermia	26.5 ± 8.3	30.1 ± 6.2^{^†}	32.3 ± 7.5^{^#,^†}	45 ± 9.8^{^#,^†}	66.8 ± 18.0^{^#,^†}
CA hypothermia	26.8 ± 7.9	32.2 ± 9.0^{^#,^†}	31.7 ± 5.7^{^#,^†}	46.2 ± 10.2^{^#,^†}	60.6 ± 16.8^#
Hematocrit %
Sham normothermia	36.7 ± 2.9	35.3 ± 1.2	34.2 ± 1.6	32.3 ± 2.7^#	35 ± 1.0
Sham hypothermia	35.8 ± 1.6	35.4 ± 2.4	35 ± 1.0	31.6 ± 1.0^#	30.8 ± 1.7^{^#,^†}
CA normothermia	37 ± 2.8	35.5 ± 1.5	33.3 ± 3.2^#	30 ± 1.9^#	30.8 ± 1.6^{^#,^†}
CA hypothermia	37 ± 4.3	36.8 ± 2.1	37.5 ± 1.6^{^†}	31 ± 1.3^#	32.8 ± 3.7^{^#,^†}
pH
Sham normothermia	7.38 ± 0.03	7.38 ± 0.03	7.39 ± 0.03	7.36 ± 0.06	7.36 ± 0.04
Sham hypothermia	7.38 ± 0.02	7.45 ± 0.16	7.36 ± 0.01	7.37 ± 0.03	7.39 ± 0.03
CA normothermia	7.37 ± 0.03	7.44 ± 0.03	7.39 ± 0.01	7.38 ± 0.02	7.35 ± 0.06
CA hypothermia	7.39 ± 0.03	7.43 ± 0.03	7.29 ± 0.04^{^#,^†}	7.32 ± 0.05^{^#,^†}	7.33 ± 0.03^#
Mg²⁺
Sham normothermia	0.36 ± 0.03	0.37 ± 0.03	0.37 ± 0.04	0.41 ± 0.05	0.41 ± 0.06
Sham hypothermia	0.39 ± 0.03	0.39 ± 0.04	0.40 ± 0.03	0.41 ± 0.05	0.43 ± 0.05
CA normothermia	0.36 ± 0.04	0.39 ± 0.04	0.41 ± 0.02	0.43 ± 0.04^#	0.46 ± 0.06^{^#,^†}
CA hypothermia	0.34 ± 0.05	0.43 ± 0.05^{^#,^†}	0.42 ± 0.02^{^#,^†}	0.41 ± 0.05^#	0.46 ± 0.09^{^#,^†}
K⁺
Sham normothermia	4.75 ± 0.53	4.74 ± 0.40	4.61 ± 0.37	5.25 ± 0.66^#	5.62 ± 0.98^#
Sham hypothermia	4.91 ± 0.30	4.79 ± 0.24	4.12 ± 0.35	3.75 ± 0.34^{^#,^†}	4.83 ± 0.28
CA normothermia	4.78 ± 0.35	4.84 ± 0.31	4.84 ± 0.37	5.43 ± 0.47	5.97 ± 0.42^#
CA hypothermia	4.6 ± 0.48	4.73 ± 0.45	3.89 ± 0.36^{^#,^†}	4.83 ± 0.18	5.67 ± 0.9^#

↵# P < 0.05 compared with the baseline time point within the same treatment group (compare within row), by one-way repeated-measures ANOVA.
↵† P < 0.05 compared with the sham normothermia within the same time point (compare within column) by one-way repeated-measures ANOVA.