TABLE 2

IC₅₀ values for inhibition of CYP2C8-catalyzed amodiaquine N-deethylation by various aglycones after incubation with NADPH-fortified HLM for 0 and 30 min

Structure	Substance	Average IC₅₀^{^a}		Ratio: IC₅₀₍₀₎/IC₅₀₍₃₀₎
Structure	Substance	IC₅₀₍₀₎	IC₅₀₍₃₀₎	Ratio: IC₅₀₍₀₎/IC₅₀₍₃₀₎
		μM
	Gemfibrozil	83 ± 7.1	102 ± 4.0	0.8
	Simvastatin	8.3 ± 1.1	10.2 ± 1.4	0.8
	Mefenamic acid	14.9 ± 3.0	22.0 ± 1.8	0.7
	Atorvastatin	21.9 ± 1.3	22.5 ± 1.8	1.0
	Diclofenac	54 ± 11	57 ± 8	0.9
	Indomethacin	88 ± 16	>200 (46 ± 6)^{^b}	<0.45
	Dihydroketoprofen	>200 (41 ± 4)^{^b}	>200 (44 ± 3)^{^b}	1.0
	Ibuprofen	>200 (23 ± 3)^{^b}	>200 (23 ± 1)^{^b}	1.0
	Ketoprofen	>200 (14 ± 3)^{^b}	>200 (6 ± 5)^{^b}	<1.0
	(R)-Naproxen	>200 (17 ± 5)^{^b}	>200 (4 ± 4)^{^b}	<1.0
	(S)-Naproxen	>200 (9 ± 3)^{^b}	>200 (9 ± 3)^{^b}	1.0

↵a Data are reported as the mean ± S.D. of n = 4 determinations. IC₅₀₍₀₎ and IC₅₀₍₃₀₎ represent the IC₅₀ determined after 0 and 30 min of incubation with NADPH-fortified HLM.
↵b %inhibition observed at 200 μM ± S.D.