Relative abundance of urinary and fecal metabolites of CP-945,598 in male and female rats after oral administration of [14C]CP-945,598
| Metabolites | Male Rats | Female Rats | ||||
|---|---|---|---|---|---|---|
| Urine | Feces | Total | Urine | Feces | Total | |
| % | ||||||
| Parent | 2.7 | 2.7 | 2.2 | 2.2 | ||
| M1 | 0.1 | 10.7 | 10.8 | 0.08 | 7.8 | 7.9 |
| M2 | 0.06 | 14.8 | 14.9 | 0.2 | 34.3 | 34.5 |
| M3 | 0.07 | 1.4 | 1.5 | 0.05 | 0.8 | 0.9 |
| M5 | 2.2 | 2.2 | 2 | 2.0 | ||
| M6 | 1.39 | 11.1 | 12.5 | 0.95 | 8.9 | 9.9 |
| M7 | 0.22 | 0.2 | 0.04 | 0.0 | ||
| M8 | 0.0 | 2.1 | 2.1 | |||
| M9a | 7.2 | 7.2 | 6 | 6.0 | ||
| M9b | 1.2 | 1.2 | 0.7 | 0.7 | ||
| M9c | 1.2 | 1.2 | 0.0 | |||
| M10 | 7 | 7.0 | 8.5 | 8.5 | ||
| M12 | 0.06 | 0.1 | 0.02 | 0.0 | ||
| M14 | 0.07 | 3.4 | 3.5 | 1.4 | 1.4 | |
| M15a | 2.4 | 2.4 | 1.6 | 1.6 | ||
| M15b | 3.7 | 3.7 | 2.4 | 2.4 | ||
| M15c | 4 | 4.0 | 3.1 | 3.1 | ||
| M16 | 0.0 | 1 | 1.0 | |||
| M18 | 0.06 | 3.7 | 3.8 | 0.04 | 0.0 | |
| M20 | 0.1 | 0.1 | 0.0 | |||
| M21 | 0.47 | 0.5 | 0.2 | 0.2 | ||
| M22 | 1.6 | 1.6 | 1.1 | 1.1 | ||
| M23 | 0.9 | 0.9 | 0.0 | |||
| M25 | 0.2 | 1.3 | 1.5 | 0.8 | 0.8 | |
| M26 | 0.07 | 1.1 | 1.2 | 0.08 | 0.8 | 0.9 |