Mean percentage dose recovered in urine and feces from rats, dogs, and mice after oral administration of [14C]CP-945,598
| Animal | Dose Excreted in 0–168 h | |||
|---|---|---|---|---|
| Urine | Feces | Bile | Totala | |
| % | ||||
| Male rats (n = 3) | 3.38 | 93.4 | N.A. | 97.0 |
| Female rats (n = 3) | 2.53 | 94.7 | N.A. | 98.6 |
| Mean | 2.96 | 94.1 | N.A. | 97.8 |
| Male rats (n = 2)b | 3.74 | 22.5 | 75.0 | 102.0 |
| Female rats (n = 2)b | 1.65 | 25.5 | 67.3 | 95.8 |
| Mean | 2.70 | 24.0 | 71.2 | 98.9 |
| Male mice (n = 3/cage) | 3.44 | 95.6 | N.A. | 99.0 |
| Female mice (n = 3/cage) | 2.82 | 93.6 | N.A. | 96.4 |
| Mean | 3.13 | 94.6 | N.A. | 97.7 |
| Male dogs (n = 2) | 3.59 | 98.0 | N.A. | 101.6 |
| Female dogs (n = 2) | 6.44 | 90.6 | N.A. | 97.0 |
| Mean | 5.02 | 94.3 | N.A. | 99.3 |
| Male dog (n = 1)b | 2.97 | NA | 56.9 | 59.9 |
| Female dog (n = 1)a,b,c | 9.44 | NA | 13.4 | 22.8 |
| Mean | 6.21 | NA | 35.2 | 41.4 |