TABLE 4

Barbiturate metabolic parameters estimated from substrate disappearance in microsomal studies, scaled to hepatic blood clearance (CL_h,b) both with and without a correction for fu_mic, compared with in vivo clearance (CL_h,b)

Barbiturate Homolog	Microsomal Protein Conc.	fu_mic	Cl_int	CL_h,_b	CL_h,_b fu_mic = 1	CL_h,_b, Mean	CL_h,_b Mean fu_mic = 1	In Vivo Nonrenal CL^{^a}
	mg/ml
n-Pentyl	0.2	0.95	22	14.7	14.1	15.0	14.4	5.6
n-Pentyl	1	0.95	23	15.3	14.7
n-Hexyl	0.2	0.9	141	35.2	33.3	39.0	35.3	24.4
n-Hexyl	0.5	0.81	158	40.9	35.3
n-Hexyl	1	0.73	175	41.0	37.2
n-Heptyl	0.2	0.83	188	24.5	21.6	32.4	24.7	26.9
n-Heptyl	0.5	0.64	235	32.8	25.1
n-Heptyl	1	0.49	267	39.9	27.3
n-Octyl	0.5	0.39	250	24.1	11.8	28.4	12.1	32.6
n-Octyl	1	0.25	264	32.6	12.4
n-Octyl	1.5		255		12.0
n-Nonyl	0.2	0.4	582	24.5	12.3	32.3	12.4	31.3
n-Nonyl	0.5	0.25	615	33.6	12.9
n-Nonyl	1	0.17	558	38.7	11.9

Cl_int, μl · min⁻¹ · mg⁻¹; CL_h,_b, ml · min⁻¹ · kg⁻¹.
↵a Toon and Rowland, 1983.