Barbiturate Homolog | Microsomal Protein Conc. | fumic | Clint | CLh,b | CLh,b fumic = 1 | CLh,b, Mean | CLh,b Mean fumic = 1 | In Vivo Nonrenal CLa |
---|---|---|---|---|---|---|---|---|
mg/ml | ||||||||
n-Pentyl | 0.2 | 0.95 | 22 | 14.7 | 14.1 | 15.0 | 14.4 | 5.6 |
n-Pentyl | 1 | 0.95 | 23 | 15.3 | 14.7 | |||
n-Hexyl | 0.2 | 0.9 | 141 | 35.2 | 33.3 | 39.0 | 35.3 | 24.4 |
n-Hexyl | 0.5 | 0.81 | 158 | 40.9 | 35.3 | |||
n-Hexyl | 1 | 0.73 | 175 | 41.0 | 37.2 | |||
n-Heptyl | 0.2 | 0.83 | 188 | 24.5 | 21.6 | 32.4 | 24.7 | 26.9 |
n-Heptyl | 0.5 | 0.64 | 235 | 32.8 | 25.1 | |||
n-Heptyl | 1 | 0.49 | 267 | 39.9 | 27.3 | |||
n-Octyl | 0.5 | 0.39 | 250 | 24.1 | 11.8 | 28.4 | 12.1 | 32.6 |
n-Octyl | 1 | 0.25 | 264 | 32.6 | 12.4 | |||
n-Octyl | 1.5 | 255 | 12.0 | |||||
n-Nonyl | 0.2 | 0.4 | 582 | 24.5 | 12.3 | 32.3 | 12.4 | 31.3 |
n-Nonyl | 0.5 | 0.25 | 615 | 33.6 | 12.9 | |||
n-Nonyl | 1 | 0.17 | 558 | 38.7 | 11.9 |
Clint, μl · min−1 · mg−1; CLh,b, ml · min−1 · kg−1.
↵a Toon and Rowland, 1983.