Noncompartmental pharmacokinetic parameters of SB939 estimated in mice, rats, and dogs (after single intravenous and oral doses)
Data for rat and dog are the mean ± S.D.
| Parameter | Mouse | Rat (n = 3) | Dog (n = 3) |
|---|---|---|---|
| Intravenous | |||
| Dose (mg/kg) | 10 | 2 | 2 |
| CL (l · h−1 · kg−1) | 9.2 | 4.5 ± 1.8 | 1.5 ± 0.2 |
| Vss (l/kg) | 3.5 | 1.7 ± 0.1 | 4.2 ± 0.4 |
| t1/2 (h) | 2.3 | 0.9 ± 0.1 | 3.9 ± 0.3 |
| AUC0-t (ng · h−1 · ml−1) | 1083 | 491 ± 167 | 1381 ± 176 |
| AUC0-∞ (ng · h−1 · ml−1) | 1089 | 496 ± 171 | 1390 ± 177 |
| Oral | |||
| Dose (mg/kg) | 50a | 10 | 10 |
| tmax (h) | 0.17 | 0.3 ± 0.2 | 0.8 ± 0.4 |
| Cmax (ng/ml) | 2632 | 43 ± 11 | 1537 ± 314 |
| t1/2 (h) | 2.4 | 2.0 ± 0.6 | 4.1 ± 0.6 |
| AUC0-t (ng · h−1 · ml−1) | 1836 | 61 ± 16 | 4481 ± 1086 |
| AUC0-∞ (ng · h−1 · ml−1) | 1841 | 70 ± 17 | 4527 ± 1078 |
| CL/F (l · h−1 · kg−1) | 27 | 148 ± 37 | 2.3 ± 0.5 |
| V/F (l/kg) | 95 | 418 ± 127 | 13.7 ± 4.0 |
| F (%) | 34 | 2.8b | 65b |