Kis and Kii values for AOX
Each value reflects an average ± S.E. for two determinations.
| Inhibitor | Kis | Kii | Kii/Kis | IC50a |
|---|---|---|---|---|
| μM | ||||
| DCPIP | 19 ± 1.8 | 2.4 ± 0.18 | 0.13 | N.D. |
| β-Estradiol | 0.9 ± 0 | 0.13 ± 0 | 0.14 | 0.29 ± 0.07 |
| Menadione | 0.75 ± 0.18 | 0.12 ± 0 | 0.16 | 0.20 ± 0.04 |
| Ethinyl estradiol | 1.1 ± 0.32 | 0.23 ± 0.011 | 0.21 | 0.57 ± 0.15 |
| Domperidone | 5.3 ± 2.6 | 14 ± 2.8 | 2.6 | 3.0 ± 1.4 |
| Chlorpromazine | 0.62 ± 0.23 | 3.3 ± 0.53 | 5.3 | 0.57 ± 0.15 |
| Clozapine | 3.9 ± 0.35 | 60 ± 1.8 | 15 | 4.4 ± 1.8 |
| 6-Chloroquinazolinone | 5.4 ± 0.92 | N.D. | ||
N.D., not detected.
↵a Measured in a previous study by Obach et al. (2004).