Kinetic parameters for CZN before drug administration (day 22) and after drug administration (day 50)
Values are expressed as mean ± S.E. n = 10. Kinetic parameters were not significantly different among groups before drug administration.
| CZN Parameter | EtOH | Nicotine | EtOH + Nicotine | |||
|---|---|---|---|---|---|---|
| Before | After | Before | After | Before | After | |
| AUC (hr · μg/ml) | 54.8 ± 7.9 | 56.6 ± 13.6 | 44.8 ± 6.2 | 29.5 ± 5.6* | 56.8 ± 4.6 | 41.6 ± 3.2* |
| Cmax (μg/ml) | 17.5 ± 2.7 | 27.7 ± 5.7 | 20.2 ± 3.6 | 11.7 ± 2.5* | 25.3 ± 3.0 | 16.4 ± 2.0* |
| tmax (h) | 1.3 ± 0.2 | 0.9 ± 0.2 | 1.1 ± 0.2 | 1.3 ± 0.2 | 1.1 ± 0.2 | 0.7 ± 0.1* |
| t1/2 (h) | 1.3 ± 0.1 | 1.2 ± 0.1 | 0.9 ± 0.1 | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.8 ± 0.3 |
EtOH, ethanol.
↵* p < 0.05, significantly different from before drug administration within the same treatment group.