TABLE 7

Allometric relationships between pharmacokinetic parameters and body weights of preclinical species and predicted values in humans

Numbers in parentheses are the 95% confidence intervals.

Parameter	Allometric Exponent	Allometric Coefficient	Regression Coefficient	Predicted Value in Humans
CL	0.72 (0.62–0.83)	2871 (2234–3681)	0.985	62 (31–123)^{^a}
V_ss	1.1 (0.9–1.3)	2799 (1841–4246)	0.982	313 (99–977)^{^b}