Relative abundance of circulating metabolites of CP-945,598 in rats, dogs, and mice after oral administration of [14C]CP- 945,598
| Metabolites | Rats (Male/Female) | Mice (Male/Female) | Dogs (Male/Female) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 HPD | 2 HPD | 4 HPD | 8 HPD | 24 HPD | 4 HPD | 12 HPD | 1 HPD | 4 HPD | 8 HPD | |
| % | ||||||||||
| Parent (X) | 18.1/52.6 | 18.5/36.0 | 10.0/45.8 | ND/18.1 | 1.9/2.3 | 2.2/2.9 | 40.5/33.6 | 8.6/3.2 | 6.6/9.7 | |
| M1 | 44.8/36.0 | 37.1/41.2 | 34.6/37.7 | 18.7/45.9 | 23.1/59.6 | 58.1/59.6 | 51.4/49.9 | 52.1/58.4 | 46.6/30.9 | 57.4/25.8 |
| M2 | 2.9/ND | 4.8/5.0 | 3.2/5.9 | ND/6.5 | ND/3.9 | 2.3/2.7 | 2.0/1.4 | 1.4/5.2 | 37.0/50.6 | 23.1/36.2 |
| M3 | 18.2/ND | 16.1/2.5 | 35.7/5.4 | 40.8/9.6 | 15.8/12.6 | 12.1/11.6 | ||||
| M4 | 8.5/6.9 | 16.1/8.7 | 5.2/3.8 | 21.3/9.8 | 56.0/23.1 | 9.7/10.8 | 10.4/10.5 | 4.1/1.4 | ND/2.6 | |
| M5 | 2.8/3.6 | 4.2/2.2 | 4.1/1.0 | 19.2/2.7 | 20.9/7.4 | 1.5/1.1 | 2.2/1.9 | |||
| M6 | 4.1/ND | 2.1/4.5 | 4.8/0.3 | ND/6.6 | 1.4/2.1 | 1.3/2.0 | 0.37/1.5 | 3.47/10.1 | 6.7/9.4 | |
| M9 | 0.7/1.7 | 2.0/2.4 | ||||||||
| M20 | 0.8/0.5 | 2.0/1.1 | ||||||||
| M26 | 3.5/3.1 | 8.6/10.8 | ||||||||
HPD, hours postdose; ND, not detected.