TABLE 4

Mean pharmacokinetic parameters for total radioactivity in rats, dogs, and mice after oral administration of [¹⁴C]CP-945,598

Animals	T_max	C_max	AUC_{(0–t last)}	AUC_(0–∞)	t_1/2
	h	ng/ml	ng · h/ml		h
Male rats (n = 3)	2.0	12,969	124,534	128,061	31.5
Female rats (n = 3)	6.7	13,093	238,015	242,869	31.1
Mean	4.4	13,031	181,275	185,465	31.3
Male mice (n = 3)/cage	2.0	9170	143,000	N.A.	7.2
Female mice (n = 3)/cage	2.0	11,600	139,000	N.A.	7.2
Mean	2.0	10,385	141,000	N.A.	7.2
Male dogs (n = 2)	1.0	2330	26,900	29,000	11.1
Female dogs (n = 2)	1.0	2250	23,600	25,700	14.0
Mean	1.0	2290	25,250	27,350	12.6