Reactions | Liver Microsomes | Inhibitory Effects, IC50 | ||
---|---|---|---|---|
ANF | Proadifen | Metyrapone | ||
μM | ||||
BROD | BNF pretreated | 0.00248 ± 0.00084 | 47.1 ± 3.7 | 40.8 ± 4.6 |
PB pretreated | >100 | 0.688 ± 0.161 | 0.806 ± 0.663 | |
cDNA-expressed CYP2B1 | N.D. | 38.1 ± 1.3 | 1.85 ± 1.11 | |
BUP hydroxylation | BNF pretreated | >100 | >100 | 41.8 ± 3.4 |
PB pretreated | >100 | 1.21 ± 0.49 | 3.89 ± 1.54 | |
cDNA-expressed CYP2B1 | N.D. | 14.9 ± 3.7 | 7.52 ± 0.54 |
N.D., not determined.