Noncompartmental analysis of plasma and brain ECF concentration-time profiles for rats administered 400, 600, or 800 mg/kg GHB i.v.
Data shown are mean ± S.D., n = 4/dose.
| GHB Dose | Plasma AUC | Brain ECF AUC | Overall Partition Coefficient |
|---|---|---|---|
| mg · min/ml | mg · min/ml | Brain AUC/Plasma AUC | |
| 400 mg/kg | 66.0 ± 13 | 4.9 ± 1 | 0.079 ± 0.01 |
| 600 mg/kg | 124 ± 23* | 8.7 ± 3 | 0.070 ± 0.02 |
| 800 mg/kg | 145 ± 26* | 11.2 ± 3* | 0.070 ± 0.02 |
↵* P < 0.05 vs. 400 mg/kg alone.