Cytochrome P450 2C19 alleles assessed as part of the meta-analysis (study 6) and their corresponding genotypes, predicted metabolizer phenotypes, and distribution
| Gene (No.)a | Predicted Phenotype (No.)a | Genotype | LD Population No. | MD Population No. |
|---|---|---|---|---|
| % | % | |||
| CYP2C19 (370/335) | UM (99/91) | *1/*17 | 88 (23.7) | 82 (24.4) |
| *17/*17 | 11 (2.9) | 9 (2.6) | ||
| EM (173/156) | *1/*1 | 173 (46.7) | 156 (46.5) | |
| IM (82/75) | *1/*2 | 75 (20.2) | 68 (20.2) | |
| *1/*3 | 3 (0.8) | 3 (0.8) | ||
| *1/*8 | 2 (0.5) | 2 (0.5) | ||
| *1/*6 | 1 (0.2) | 1 (0.2) | ||
| *1/*4 | 1 (0.2) | 1 (0.2) | ||
| PM (13/12) | *2/*2 | 12 (3.2) | 11 (3.2) | |
| *2/*3 | 1 (0.2) | 1 (0.2) |
LD, loading dose; MD, maintenance dose.
↵a Presented as loading dose population/maintenance dose population.