Parameter (units) | Lapatinib | Total Radioactivity | Ratio |
---|---|---|---|
Cmax (mg/l) | 0.33 (0.15–1.07) | 0.72 (0.40–1.69) | |
Tmax (h) | 4.05 (2.53–5.97) | 4.03 (3.03–5.97) | |
AUC∞ (h · mg/l) | 3.58 (2.31–13.0) | 6.79 (4.51–23.0) | 0.54 (0.47–0.57) |
t1/2 (h) | 14.8 (11.5–20.5) | 5.59 (4.50–14.6)a | |
Urinary recovery (%dose) | 1.15 (0.49–1.61) | ||
Fecal recovery (%dose) | 27.0 (2.68–66.9) | 91.7 (60.3–98.3) | 0.33 (0.04–0.72) |
Total recovery (%dose) | 93.0 (61.6–99.7) |
↵a Value probably underestimated because of detection limits for radioactivity.