Inhibitor | AUCI/AUC | References | ||
---|---|---|---|---|
DES | DEX | MET | ||
Cimetidine (1000–1200 mg/day)a | 1.6 | 1.6 | Mutschler et al., 1984; Steiner and Spina, 1987 | |
Duloxetine (60 mg/day) | 2.1 | 1.8 | Preskorn et al., 2007; Patroneva et al., 2008 | |
Paroxetine (20 mg/day)a | 4.8 | 4.2 | Goryachkina et al., 2008; Nichols et al., 2009 | |
Quinidine (50–100 mg/day) | 3.2 | 16.3 | 3.2 | Ayesh et al., 1991; Leemann et al., 1993; Abdul Manap et al., 1999 |
Quinidine (200 mg/day) | 7.5 | Brøsen and Gram, 1989 | ||
Ritonavir (200 mg) | 1.3 | 2.9 | Aarnoutse et al.. 2005; Wyen et al., 2008 | |
Sertraline (50–100 mg/day) | 1.7 | 1.7 | Kurtz et al., 1997; Preskorn et al., 2007 |
DES, desipramine; DEX, dextromethorphan; MET, metoprolol.
↵a Time-dependent inhibitor of CYP2D6.