TABLE 2

Frequency of hybrid genes per sample type

The frequency of hybrids genes in CYP2D6*4 and CYP2D6*10 samples is reported for both heterozygous or homozygous and heterozygous alone. We did not determine whether one or both chromosomes contained a hybrid tandem in homozygous samples. For this reason, to determine the risk that a CYP2D6*4 or CYP2D6*10 allele is actually in a hybrid tandem arrangement, we determined the percentage of heterozygous samples for each, which had a hybrid tandem. The “Any homozygous genotype” row included any sample with an initial homozygous genotype except those with duplications. Finally, the frequency of hybrid genes in samples originally genotyped as having duplications is shown. The percentage of hybrid alleles in the 1390 samples is also shown by category, although note that the sample set was not from a random population but was purposefully enriched for samples with CYP2D6*4, CYP2D6*10, duplication, and homozygous genotypes; thus, frequency of hybrid genes in a general population is likely to be different.