TABLE 2

Intrinsic clearance in cryopreserved HepaRG cells, cryopreserved human hepatocytes, and in vivo

Substrate	HepaRG		Hepatocytes		In Vivo
Substrate	CL_int	CL_{int, u}^{^a}	CL_int	CL_{int, u}^{^a}	CL_{int, u, Obs}^{^b}
	μl · min⁻¹ · 10⁶ cells⁻¹	ml · min⁻¹ · kg⁻¹	μl · min⁻¹ · 10⁶ cells⁻¹	ml · min⁻¹ · kg⁻¹	ml · min⁻¹ · kg⁻¹
Alprenolol	25.1	69.2	49.3	136	117
Antipyrine			0.083	0.216	0.604
Bufuralol	88.0	229	51.3	133	63.8
Caffeine	6.3	16.3	3.09	8.03	2.79
Chlorpromazine	252.2	2142	82.5	701.1	278
Clomipramine	122.5	1688	134	1851	1047
Diclofenac	16.9	44.3	22.8	59.8	354
Domperidone			59.5	255.4	271
Fenoprofen	5.31	13.9	8.5	22.1	34.3
Fluphenazine	71.6	404	121	683	1581
Flurbiprofen			5.94	15.5	92.0
Furosemide			0.99	2.57	84.9
Glimepiride	6.17	16.1	5.62	14.7	5.10
Glyburide	10.1	26.7	6.54	17.3	347
Ibuprofen			3.29	8.77	56.2
Imipramine	23.6	128	86.8	472	299
Ketoprofen			6.28	16.3	74.9
Labetalol	7.47	20.0	21.6	57.7	450
Lidocaine	12.1	32.5	21.3	57.1	78.4
Methylprednisolone			23.7	61.5	45.0
Metoprolol	8.41	22.2	13.0	34.2	46.5
Mianserin	54.6	167	50.4	154.2	1463
Naproxen	16.4	42.5	4.91	12.8	5.86
Nifedipine	28.7	74.5	17.1	44.4	196
Phenacetin	13.7	36.0	8.94	23.5	615
Prednisolone	8.49	22.1	28.3	73.5	27.1
Prochlorperazine	144	667	51.7	240	29240
Promazine	51.6	243	30.9	146	1595
Propafenone			47.8	157	328
(−)-Propranolol	41.4	116	51.3	144	214
Propranolol			48.6	136	260
Quinidine	20.3	59.6	13.5	39.6	33.3
Risperidone	4.02	11.1	19.2	52.8	43.0
Sildenafil			14.8	39.5	89.9
Theophylline			1.73	4.48	2.60
Timolol			8.10	21.0	48.9
Tolbutamide	0.207	0.541	4.68	12.2	0.38
Trazodone			12.2	32.1	32.5
Trimipramine			196	1565	1344
Verapamil	122	397	77.1	250.5	310
S-Warfarin			6.93	18.3	3.31

↵a CL_{int, u} is CL_int corrected for calculated incubation f_{u, inc} and scaled to whole body.
↵b CL_{int, u, Obs} is intrinsic clearance calculated from the in vivo clearance using the well stirred liver model.