Substrate | HepaRG | Hepatocytes | In Vivo | ||
---|---|---|---|---|---|
CLint | CLint, ua | CLint | CLint, ua | CLint, u, Obsb | |
μl · min−1 · 106 cells−1 | ml · min−1 · kg−1 | μl · min−1 · 106 cells−1 | ml · min−1 · kg−1 | ml · min−1 · kg−1 | |
Alprenolol | 25.1 | 69.2 | 49.3 | 136 | 117 |
Antipyrine | 0.083 | 0.216 | 0.604 | ||
Bufuralol | 88.0 | 229 | 51.3 | 133 | 63.8 |
Caffeine | 6.3 | 16.3 | 3.09 | 8.03 | 2.79 |
Chlorpromazine | 252.2 | 2142 | 82.5 | 701.1 | 278 |
Clomipramine | 122.5 | 1688 | 134 | 1851 | 1047 |
Diclofenac | 16.9 | 44.3 | 22.8 | 59.8 | 354 |
Domperidone | 59.5 | 255.4 | 271 | ||
Fenoprofen | 5.31 | 13.9 | 8.5 | 22.1 | 34.3 |
Fluphenazine | 71.6 | 404 | 121 | 683 | 1581 |
Flurbiprofen | 5.94 | 15.5 | 92.0 | ||
Furosemide | 0.99 | 2.57 | 84.9 | ||
Glimepiride | 6.17 | 16.1 | 5.62 | 14.7 | 5.10 |
Glyburide | 10.1 | 26.7 | 6.54 | 17.3 | 347 |
Ibuprofen | 3.29 | 8.77 | 56.2 | ||
Imipramine | 23.6 | 128 | 86.8 | 472 | 299 |
Ketoprofen | 6.28 | 16.3 | 74.9 | ||
Labetalol | 7.47 | 20.0 | 21.6 | 57.7 | 450 |
Lidocaine | 12.1 | 32.5 | 21.3 | 57.1 | 78.4 |
Methylprednisolone | 23.7 | 61.5 | 45.0 | ||
Metoprolol | 8.41 | 22.2 | 13.0 | 34.2 | 46.5 |
Mianserin | 54.6 | 167 | 50.4 | 154.2 | 1463 |
Naproxen | 16.4 | 42.5 | 4.91 | 12.8 | 5.86 |
Nifedipine | 28.7 | 74.5 | 17.1 | 44.4 | 196 |
Phenacetin | 13.7 | 36.0 | 8.94 | 23.5 | 615 |
Prednisolone | 8.49 | 22.1 | 28.3 | 73.5 | 27.1 |
Prochlorperazine | 144 | 667 | 51.7 | 240 | 29240 |
Promazine | 51.6 | 243 | 30.9 | 146 | 1595 |
Propafenone | 47.8 | 157 | 328 | ||
(−)-Propranolol | 41.4 | 116 | 51.3 | 144 | 214 |
Propranolol | 48.6 | 136 | 260 | ||
Quinidine | 20.3 | 59.6 | 13.5 | 39.6 | 33.3 |
Risperidone | 4.02 | 11.1 | 19.2 | 52.8 | 43.0 |
Sildenafil | 14.8 | 39.5 | 89.9 | ||
Theophylline | 1.73 | 4.48 | 2.60 | ||
Timolol | 8.10 | 21.0 | 48.9 | ||
Tolbutamide | 0.207 | 0.541 | 4.68 | 12.2 | 0.38 |
Trazodone | 12.2 | 32.1 | 32.5 | ||
Trimipramine | 196 | 1565 | 1344 | ||
Verapamil | 122 | 397 | 77.1 | 250.5 | 310 |
S-Warfarin | 6.93 | 18.3 | 3.31 |