Chemical | Concentration | Relative mRNA Expression | |||
---|---|---|---|---|---|
Rat Hepatocytes | Human Hepatocytes | ||||
rCAR | rPXR | hCAR | hPXR | ||
Fold increase over control | |||||
DMSO | 0.1% v/v | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 |
Bilobalide | 1 μM | 1.3 ± 0.5 | 1.1 ± 0.1 | N.A. | N.A. |
3 μM | 1.3 ± 0.4 | 1.0 ± 0.3 | N.A. | N.A. | |
10 μM | 1.1 ± 0.3 | 1.4 ± 0.2 | 1.4 ± 0.2 | 0.7 ± 0.0 | |
25 μM | N.A. | N.A. | 1.4 ± 0.1 | 1.2 ± 0.2 | |
30 μM | 1.0 ± 0.3 | 0.8 ± 0.5 | N.A. | N.A. | |
50 μM | N.A. | N.A. | 1.4 ± 0.0 | 0.4 ± 0.0 |
N.A., not available.