Parent | Metabolite | Observed AUCm/AUCp (Range) | In Vitro System | Equation Used | Predicted AUCm/AUCp | Predicted/Observed (Range) |
---|---|---|---|---|---|---|
Dextromethorphan | Dextrorphan | 0.61 (0.52–0.70) | Pooled HLM | 6 | 2.3 | 3.8 (3.3–4.4) |
7 | 1.3 | 2.1 (1.9–2.5) | ||||
Omeprazole | 5OH-Omeprazole | 0.48 (0.24–0.74) | Hepatocytes | 6 | 0.37 | 0.78 (0.50–1.5) |
7 | 0.36 | 0.75 (0.49–1.5) | ||||
Omeprazole | Omeprazole sulfone | 0.85 (0.79–0.94) | Pooled HLM | 6 | 2.8 | 3.3 (3.0–3.5) |
7 | 2.6 | 3.1 (2.8–3.3) | ||||
Hepatocytes | 6 | 0.90 | 1.1 (0.96–1.2) | |||
7 | 0.90 | 1.1 (0.96–1.2) |