TABLE 1
1H chemical shifts of sipoglitazar and its metabolites
| H No. | δ(ppm), J (Hz) | ||
|---|---|---|---|
| Sipoglitazar | Sipoglitazar-G1 | Sipoglitazar-G2 | |
| 1 | 7.45–7.48 (m) | 7.45–7.49 (m) | 7.45–7.50 (m) |
| 2 | 7.45–7.48 (m) | 7.45–7.49 (m) | 7.45–7.50 (m) |
| 3 | 7.90 (m) | 7.90 (m) | 7.91 (m) |
| 4 | 7.22 (s) | 7.25 (s) | 7.26 (s) |
| 5 | 5.16 (s) | 5.17 (s) | 5.17 (s) |
| 6 | 6.97 (d, J = 8.7) | 6.97 (d, J = 8.5) | 6.97 (d, J = 8.6) |
| 7 | 7.15 (d, J = 8.7) | 7.14 (d, J = 8.5) | 7.16 (d, J = 8.6) |
| 8 | 4.94 (s) | 4.92 (s) | 4.94 (s) |
| 9 | 7.49 (s) | 7.50 (s) | 7.51 (s) |
| 10 | 2.48 (m) | 2.54–2.62 (m) | 2.54–2.58 (m) |
| 11 | 2.48 (m) | 2.54–2.62 (m) | 2.54–2.58 (m) |
| 12 | 4.07 (q, J = 7.0) | ca. 4.1 (hidden) | 4.08 (q, J = 7.0) |
| 13 | 1.25 (t, J = 7.0) | 1.25 (t, J = 7.0) | 1.26 (t, J = 7.0) |
| 1′ | 5.45 (d, J = 7.7) | 5.20 (d, J = 3.6) | |
| 2′ | 3.38 (m) | 4.57 (dd, J = 9.6,3.6) | |
| 3′ | 3.45–3.52 (m) | 3.80 (m) | |
| 4′ | 3.45–3.52 (m) | 3.55 (m) | |
| 5′ | 3.89 (d, J = 8.8) | 4.20 (d, J = 10.2) | |
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