Correlation coefficients between haloperidol O-glucuronidation and typical activities in a panel of 17 HLM
| Activity (Isoform) | Haloperidol Conc. | r | p |
|---|---|---|---|
| Trifluoperazine N-glucuronidation (UGT1A4) | 25 μM | 0.469 | N.S. |
| Propofol O-glucuronidation (UGT1A9) | 0.336 | N.S. | |
| Zidovudine O-glucuronidation (UGT2B7) | 0.732 | <0.01 | |
| Trifluoperazine N-glucuronidation (UGT1A4) | 100 μM | 0.519 | <0.01 |
| Propofol O-glucuronidation (UGT1A9) | 0.48 | N.S. | |
| Zidovudine O-glucuronidation (UGT2B7) | 0.65 | <0.01 | |
| Trifluoperazine N-glucuronidation (UGT1A4) | 200 μM | 0.592 | <0.05 |
| Propofol O-glucuronidation (UGT1A9) | 0.573 | <0.05 | |
| Zidovudine O-glucuronidation (UGT2B7) | 0.663 | <0.01 |
N.S., not significant.