Phenacetin | Acetaminophen | AUC Metabolite/Parent | ||||||
---|---|---|---|---|---|---|---|---|
AUClast | t1/2 | MRT | Vss | CL | Cmax | AUClast | ||
nM · h | h | h | liter | ml · min−1 · kg−1 | nM | nM · h | ||
CC (wild-type) | ||||||||
Mean | 3290 | 0.8 | 0.7 | 11 | 264 | 621 | 1162 | 0.34 |
S.D. | 1462 | 0.3 | 0.2 | 3 | 110 | 386 | 693 | 0.07 |
CT (heterozygous) | ||||||||
Mean | 4235 | 0.4 | 0.7 | 15 | 344 | 1231 | 2797 | 0.59 |
S.D. | 1083 | 0.003 | 0.03 | 4 | 91 | 778 | 2236 | 0.35 |
TT (CYP1A2-deficient) | ||||||||
Mean | 4823 | 0.5 | 0.8 | 15 | 292 | 246 | 601 | 0.13 |
S.D. | 662 | 0.09 | 0.03 | 2 | 42 | 171 | 433 | 0.17 |
MRT, mean resonance time; Vss, volume at steady state; CL, clearance.
↵a No significant difference found between groups.