TABLE 4

Capillary depletion analysis for brain uptake of the cTfRMAb-IDS fusion protein

Data are means ± S.E. (n = 3 mice). The fusion protein was administered by intravenous injection, and brain measurements were made 60 min after injection.

FractionVD
μl/g
Brain homogenate377 ± 25
Postvascular supernatant102 ± 11
Vascular pellet49 ± 10