Age | GSTZ1 Haplotype | Cytosol | Mitochondria | |||||
---|---|---|---|---|---|---|---|---|
Activity | Expression | Ratio of Act to Exp | Activity | Expression | Ratio of Act to Exp | |||
years | pmol · min−1 · mg−1 | pmol GSTZ1/mg cytosol | pmol · min−1 · mg−1 | pmol GSTZ1/mg mitochondria | ||||
HL735 | 74 | 1C/1C | 385 | 18.18 | 21.2 | 141 | 8.53 | 16.5 |
HL733 | 70 | 1C/1B | 525 | 20.47 | 25.6 | 207 | 7.94 | 26.1 |
HL750 | 10 | 1C/1B | 572 | 28.39 | 20.1 | 304 | 11.42 | 26.6 |
HL20 | 67 | 1D/1D | 474 | 22.66 | 20.9 | 157 | 9.83 | 16.0 |
Mean ± S.D. (n = 4) | 22.0 ± 2.5 | 21.3 ± 5.8 | ||||||
HL10 | 23 | 1A/1C | 1238 | 18.67 | 66.3 | 871 | 12.63 | 68.9 |
HL97 | 21 | 1A/1C | 1460 | 22.92 | 63.7 | 465 | 9.19 | 50.6 |
HL742 | 48 | 1A/1C | 1503 | 25.18 | 59.7 | 514 | 9.87 | 52.1 |
Mean ± S.D. (n = 3) | 63.2 ± 3.4** | 57.2 ± 10.2* |
Act, activity; Exp, expression.
↵* p < 0.05 and ** p < 0.001, significantly different from noncarriers of GSTZ1A by two-tailed t test assuming unequal variances.