TABLE 4

Pharmacokinetic parameters for hαhIL-10/hIL-10 and mαmIL-10/hIL-10 immune complex

Parameters were calculated using a noncompartmental model for intravenous and subcutaneous administration.

Parameter	hIL-10/hαhIL-10 12G8 (FELA)^{^a}	hIL-10 (FELA)^{^a}	hIL-10/mαmIL-10 11D8 (FELA)^{^b}	hIL-10 (FELA)
Dose (mg/kg) and Route	hαhIL-10: 25, i.v.; hIL-10: 3.0, i.v.	3.0, i.v.	mαmIL-10: 60, i.v.; hIL-10: 20, s.c.	20.0, s.c.
Clearance (ml · day⁻¹ · kg⁻¹)	243.34	5655.89
V_ss (ml/kg)	221.46	75.27
AUC last (μg · day/ml)	11.28	0.53	4.88	1.29
t_1/2 terminal (day)	1.16	0.04	1.16	0.54
T_max (day)			0.08	0.04
C_max (μg/ml)			11.80	8.02

↵a Calculated PK parameters up to 3 days for hαhIL-10/hIL-10, but only up to 8 h for hIL-10.
↵b Calculated PK parameters only up to 48 h, because at 96 h the AUC_%Extrap_pred >25%.