TABLE 4

Concentration of total radioactivity (microgram freebase equivalent per gram tissue) in male rat tissues after a single oral administration of [¹⁴C]sunitinib

Tissue	Albino					Pigmented
Tissue	3 h	6 h	24 h	72 h	168 h	24 h	72 h	168 h	336 h
Adrenal	25.22	13.57	4.11	1.52	0.31	4.30	1.40	0.74	0.16
Bladder	3.22	2.56	0.35	—	—	0.48	—	0.06	—
Blood	1.12	0.84	0.07	—	—	0.16	—	0.06	—
Bone marrow	7.55	6.60	0.38	—	—	0.55	—	0.06	—
Brain	0.30	0.34	—	0.07	—	0.06	—	0.06	—
Brown fat	8.47	7.57	0.46	—	—	0.85	—	0.06	—
Eye	1.10	1.34	0.08	—	—	7.80	23.98	28.52	39.40
Heart	5.58	4.61	0.36	—	—	0.43	—	0.06	—
Kidney	13.24	9.43	1.43	0.16	—	1.88	0.26	0.06	—
Lachrymal gland	8.82	13.48	4.70	0.41	—	0.94	—	0.06	—
Large intestine	6.05	5.38	1.50	0.08	—	0.69	0.08	0.06	—
Liver	15.71	10.70	1.70	0.24	—	2.09	0.22	0.06	—
Lung	20.70	17.87	0.87	—	—	1.55	—	0.06	—
Lymph node	8.86	11.26	0.90	—	—	1.03	—	0.06	—
Pancreas	11.10	9.18	1.68	—	—	1.23	—	0.06	—
Pituitary gland	24.34	22.94	7.90	2.70	0.76	7.71	1.65	81.06	—
Preputial gland	12.60	10.53	13.66	0.13	—	7.53	7.84	0.06	—
Salivary gland	17.24	12.14	1.25	0.14	—	3.52	—	0.06	—
Skeletal muscle	2.92	2.30	0.16	—	—	0.30	—	0.06	—
Skin (abdomen)	2.81	3.45	3.39	0.27	—	5.57	0.64	0.58	0.30
Small intestine	8.91	5.54	1.55	0.15	—	0.82	0.07	0.06	—
Spinal cord	0.19	0.29	—	—	—	—	—	0.06	—
Spleen	20.52	16.24	1.23	0.20	—	1.63	0.13	0.06	—
Stomach	10.15	9.30	1.13	-	—	0.67	—	0.06	—
Testis	0.79	0.90	2.80	0.39	0.30	2.27	0.87	0.91	0.17
Thymus	6.89	6.43	0.58	—	—	0.67	—	0.06	—
Thyroid gland	18.40	18.76	1.40	0.24	—	0.72	—	0.06	—
Uveal	2.63	5.08	0.13	—	—	18.79	147.37	111.78	100.17

—, Not detected.