Substrate | Hk/Dk | |||||
---|---|---|---|---|---|---|
Human | Rat | Guinea Pig | ||||
Cytosol | Hepatocytes | Cytosol | Hepatocytes | Cytosol | S-9 Supplemented | |
2-[2H]Quinoxalinea | 5.0 | N.D.c | 5.1 | N.D. | 4.7 | N.D. |
1-[2H]Phthalazinea | 5.1 | N.D. | 5.0 | N.D. | 4.9 | N.D. |
Quinolineb | 5.5 | N.D. | 6.1 | N.D. | 6.0 | N.D. |
Carbazeranb | 4.8 | 1.5 | 5.0 | 4.6 | 6.0 | 5.0 |
Zoniporideb | 5.8 | 1.9 | 3.6 | 2.7 | 4.8 | 1.5 |
N.D., not determined.
↵a Determined from the ratio of the peak area for m/z 148 (Hk, corrected for the M + 1 contribution from the m/z 147 ion) to the m/z 147 ion (Dk).
↵b Determined from the ratio of the rate constants for disappearance of 2-[1H]quinoline (Hk) and 2-[2H]quinoline (Dk), 1-[1H]carbazeran (Hk) and 1-[2H]carbazeran (Dk), and 2-[1H]zoniporide (Hk) and 2-[2H]zoniporide (Dk).