Total plasma and brain concentrations and derived Kp values of administered test compounds and formed metabolites in wild-type and mdr1a-deficient rats after a 3-day continuous minipump treatment
Values are shown as means ± S.E.M. (n = 3–5).
| Compound | Wild-Type Rats | mdr1a-Deficient Rats | ||||
|---|---|---|---|---|---|---|
| Plasma | Brain | Kp | Plasma | Brain | Kp | |
| ng/ml | ng/g | ng/ml | ng/g | |||
| Citalopram | 27 ± 2.4 | 265 ± 16 | 10 ± 0.78 | 35 ± 5.8 | 1198 ± 289 | 33 ± 2.7 |
| Venlafaxine | 50 ± 3.7 | 158 ± 4.6 | 3.3 ± 0.29 | 63 ± 11 | 389 ± 33 | 6.3 ± 0.60 |
| O-Desmethyl-venlafaxine | 4.5 ± 1.4 | 4.4 ± 0.89 | 1.0 ± 0.10 | 11 ± 3.3 | 33 ± 7.8 | 3.3 ± 0.38 |
| N-Desmethyl-venlafaxine | 6.8 ± 1.5 | 9.3 ± 1.1 | 1.4 ± 0.14 | 10 ± 4.2 | 79 ± 21 | 8.9 ± 1.7 |
| Risperidone | 194 ± 34 | 41 ± 0.88 | 0.22 ± 0.04 | 168 ± 25 | 295 ± 36 | 1.9 ± 0.44 |
| 9-OH-risperidone | 153 ± 24 | 22 ± 1.6 | 0.15 ± 0.03 | 192 ± 41 | 289 ± 14 | 1.7 ± 0.41 |
| Aripiprazole | 18 ± 5.3 | 3.0 ± 0.60 | 0.19 ± 0.04 | 22 ± 1.0 | 14 ± 2.1 | 0.64 ± 0.07 |