KDIE on the pharmacokinetic parameters for carbazeran and zoniporide administered intravenously or orally as a cassette dose to male Hartley guinea pigs and male Sprague-Dawley rats
| Route | Drug | Species | Mean KDIE (D/H) | |||||
|---|---|---|---|---|---|---|---|---|
| Cmax | AUC | t1/2 | ||||||
| Mean | S.D. | Mean | S.D. | Mean | S.D. | |||
| Intravenous | Carbazeran | Guinea pig | N.A. | N.A. | 5.9 | 0.7 | 0.8 | 0.1 |
| Rat | N.A. | N.A. | 2.2 | 0.6 | 1.2 | 0.2 | ||
| Zoniporide | Guinea pig | N.A. | N.A. | 1.7 | 0.2 | 1.2 | 0.3 | |
| Rat | N.A. | N.A. | 1.0 | 0.0 | 1.5 | 0.3 | ||
| Oral | Carbazeran | Guinea pig | 22.5 | 7.6 | 21.4 | 4.3 | 0.5 | 0.1 |
| Rat | 1.5 | 0.0 | 2.3 | 0.2 | 1.3 | 0.1 | ||
| Zoniporide | Guinea pig | 1.0 | 0.2 | 1.2 | 0.1 | 1.2 | 0.2 | |
| Rat | 0.7 | 0.1 | 0.6 | 0.2 | 1.1 | 0.0 | ||
N.A., not applicable.